منابع مشابه
Thalamic mechanism of pain: shell theory of thalamic nociception.
In both cats and Japanese macaques, there are nociceptive specific (NS) and wide dynamic range (WDR) neurons in the shell region of the caudal ventrobasal (VB) complex of the thalamus. This comprises both the nucleus ventralis posteromedialis proper (VPM proper), and the nucleus ventralis posterolateralis (VPL). These two classes of nociceptive neurons are spatially segregated, WDR neurons bein...
متن کاملNociception
Nociception, the sensory mechanism that allows animals to sense and avoid potentially tissue-damaging stimuli, is critical for survival. This process relies on nociceptors, which are specialized neurons that detect and respond to potentially damaging forms of energy - heat, mechanical and chemical - in the environment. Nociceptors accomplish this task through the expression of molecules that fu...
متن کاملStudies on inhibitory mechanism of microtubule inhibitors
Microtubules are key components of the cytoskeleton of eukaryotic cells and play important roles in many aspects of biological functions. Development of microtubule inhibitors, which interfere with microtubule assembly and disassembly specific in the M phase, is useful for the investigation of the biological function of microtubules and microtubule-associated proteins (MAPs) as well as for canc...
متن کاملInhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats
Extracellular ATP is known to mediate synaptic transmission as a neurotransmitter or a neuromodulator via ionotropic P2X and metabotropic P2Y receptors. Several lines of evidence have suggested that ATP facilitates pain transmission at peripheral and spinal sites via the P2X receptors, in which the P2X3 subtype is considered as an important candidate for the effect. Conversely, we previously fo...
متن کاملPostoperative Models of Nociception.
Even though it is a costly, poorly understood problem, very little effort has been dedicated toward research on the mechanisms of acute postoperative pain. Presumably, if we learn more about the etiology of acute incisional pain and the sensory processes that intensify pain after surgery, new treatment methods can be advanced. Since the mid-1990s, our group and others have developed and charact...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1983
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)60222-2